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Antigenic Specificity | CD136 Phospho-specific |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~185 kDa of human CD136 protein. It also reacts with mouse and rat. The other species are not tested. CD136, a transmembrane receptor tyrosine kinase, also known as Macrophage stimulating 1 receptor (MST1R) and RON (Recepteur d'origine nantais), is a member of the MET proto-oncogene family (63% homology), and is the receptor for macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. Binding of MSP to CD136 stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a upregulation of CD136 catalytic activity and subsequent activation of downstream signaling molecules. In addition, CD136 contains putative autophosph |
Immunogen | Antigen Preparation: A synthetic peptide containing epitope -EPYYS- with a dually phosphorylation sites Y1238/9 of the human CD136. |
Other Names | n/a |
Gene, Accession # | [CD136 (RON) (pY1238/1239)] |
Catalog # | MBS462024 |
Price | $285 |
Order / More Info | CD136 Phospho-specific Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |