Edit |   |
---|---|
Antigenic Specificity | Mouse CD22 |
Clone | [Cy34.1] |
Host Species | Mouse |
Reactive Species | mouse |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.025 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is invol |
Immunogen | n/a |
Other Names | [Mouse CD22; B-cell receptor CD22; Cd22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD22; Lyb-8; Siglec2] |
Gene, Accession # | [CD22], Gene ID: 12483, NCBI: NP_001036782.1, UniProt: P35329 |
Catalog # | MBS2553783 |
Price | $75, $135 |
Order / More Info | Mouse CD22 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Symington FW et al. 1982. Immunogenetics 16:381. 2. Erickson LD et al. 1996. Int Immunol 8:1121. 3. Doody GM et al. 1995. Science 269:242. |