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Antigenic Specificity | FOLR1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total FOLR1 protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.Elwood P.C., J. Biol. Chem. 264:14893-14901(1989).Lacey S.W., J. Clin. Invest. 84:715-720(1989).Campbell I.G., Cancer Res. 51:5329-5338(1991). |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human FOLR1. |
Other Names | [Folate receptor alpha; FR-alpha; Folate receptor 1; Folate receptor; adult] |
Gene, Accession # | [FOLR1], Gene ID: 2348, NCBI: NP_000793.1, UniProt: P15328 |
Catalog # | MBS9412548 |
Price | $200, $255 |
Order / More Info | FOLR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |