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Antigenic Specificity | Phospho-ABL1-Y204 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9; 22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6-or 7-kb mRNA transcript, with alternatively spliced first exon |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding Y204 of human ABL1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [ABL; JTK7; p150; c-ABL; v-abl; bcr/abl] |
Gene, Accession # | [ABL1-Y204], Gene ID: 25, NCBI: NP_005148.2, UniProt: P00519 |
Catalog # | MBS8527409 |
Price | $310 |
Order / More Info | Phospho-ABL1-Y204 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |