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Antigenic Specificity | GRB2 |
Clone | [3B2-G2-E5] |
Host Species | Mouse |
Reactive Species | human, rat, mouse, monkey |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody detects endogenous levels of GRB2 and does not cross-react with related proteins. Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Purified recombinant human GRB2 protein fragments expressed in E Coli. |
Other Names | [Abundant SRC homology; Adapter protein GRB2; ASH; Ash protein; EGFRBP GRB2; Epidermal growth factor receptor binding protein; Epidermal growth factor receptor binding protein GRB2; GRB 2; GRB2 adapter protein; Grb2; GRB2_HUMAN; Grb3 3] |
Gene, Accession # | [GRB2], Gene ID: 2885, NCBI: NP_002077.1, UniProt: P62993 |
Catalog # | MBS9400488 |
Price | $200, $255 |
Order / More Info | GRB2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |