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Antigenic Specificity | Apolipoprotein E |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat. |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit IgG polyclonal antibody for Apolipoprotein E (APOE) detection. Background: APOE is also known as AD2 or LPG. The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants. |
Immunogen | Immunogen: E Coli-derived mouse Apolipoprotein E recombinant protein (Position: D55-Q294). Mouse Apolipoprotein E shares 75% and 94.6% amino acid (aa) sequence identity with human and rat Apolipoprotein E, respectively. |
Other Names | [AD2; Apo E; APOE; Apo-E; Apolipoprotein E; Apolipoprotein E3; LPG; P08226; Apolipoprotein E; apolipoprotein E], [Apoe; Apoe; Apo-E; AI255918; Apo-E] |
Gene, Accession # | [APOE], Gene ID: 11816, NCBI: NP_001292748.1, UniProt: P08226 |
Catalog # | MBS178486 |
Price | $315 |
Order / More Info | Apolipoprotein E Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. APOE epsilon variants increase risk of warfarin-related intracerebral hemorrhage.Falcone GJ, et al. Neurology, 2014 Sep 23. 2. Calabuig-Navarro MV, et al. Apolipoprotein E genotype has a modest impact on the postprandial plasma response to meals of varying fat composition in healthy men in a randomized controlled trial. J Nutr, 2014 Nov. |