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Antigenic Specificity | TNF-R1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: TNF-R1 antibody detects endogenous levels of total TNF-R1. Description: TNF-alpha is an important cytokine produced by numerous cell types including neutrophils, activated lymphoctyes, macrophages an NK cells. It plays a critical role in inflammatory responses and in apoptosis (1). TNF-alpha exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-alpha is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells (2). Antagonists to TNF-alpha have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders (3). The two receptors for TNF-alpha, TNF-R1 (55 kDa) and TNF-R2 (75 |
Immunogen | Immunogen: A synthesized peptide derived from human TNF-R1 Subcellular Location: Cell Membrane. Golgi Apparatus Membrane. Secreted. A secreted form is produced through proteolytic processing and secreted. Lacks a golgi-retention motif, is not membrane bound and therefore is secreted. |
Other Names | [CD120a; FPF; MGC19588; p55; p55-R; p60; TBP1; TBPI; TNF R; TNF R55; TNF-R1; TNF-RI; TNFAR; TNFR-I; TNFR1; TNFR55; TNFR60; TNFRI; TNFRSF1a; TNR1A_HUMAN; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor superfamily, member 1A; Tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; Tumor necrosis factor-binding protein 1] |
Gene, Accession # | [TNF-R1], Gene ID: 7132, NCBI: NP_001056.1, UniProt: P19438 |
Catalog # | MBS9607104 |
Price | $240, $280 |
Order / More Info | TNF-R1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |