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Antigenic Specificity | OTUD7B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Medi |
Immunogen | Immunogen: Recombinant Human OTU domain-containing protein 7B protein (235-347AA) |
Other Names | [OTU domain-containing protein 7B; Cellular zinc finger NF-kappa-B protein1; OTUD7B; ZA20D1] |
Gene, Accession # | [OTUD7B], Gene ID: 56957, NCBI: NP_064590.2, UniProt: Q6GQQ9 |
Catalog # | MBS7108319 |
Price | $160, $235 |
Order / More Info | OTUD7B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |