canine Factor VIII, Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-canine Factor VIII, antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | canine Factor VIII, |
| Clone | polyclonal |
| Host Species | Sheep |
| Reactive Species | n/a |
| Isotype | n/a |
| Format | peroxidase (HRP) conjugate |
| Size | 0.2 mg |
| Concentration | IgG-HRP concentration is mg/ml, determined by absorbance using an extinction coefficient (E1%280) of 14. |
| Applications | n/a |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Prior to conjugation, this antibody was specific for canine FVIII as demonstrated by immunoelectrophoresis and ELISA. Factor VIII is a large glycoprotein (320 kDa) synthesized in the liver. The majority of Factor VIII is cleaved during expression, resulting in a mixture of partially cleaved forms ranging in size from 200-280 kDa. The FVIII is stabilized in circulation through non-covalent association with von Willebrand Factor. The concentration of FVIII in normal human plasma is typically 200 ng/mL. In canine plasma, the FVIII activity is 5-7 fold higher relative to human plasma. FVIII is a pro-cofactor that is activated through limited proteolysis by thrombin. In this process FVIIIa dissociates from vWF to combine with activa |
| Immunogen | Immunogen: Recombinant canine FVIII (cFVIII). |
| Other Names | [Factor VIII:C, canine], [F8; F8; AHF; F8B; F8C; HEMA; FVIII; DXS1253E; F8C; AHF] |
| Gene, Accession # | Gene ID: 2157, NCBI: AAA52484.1, UniProt: P00451 |
| Catalog # | MBS512215 |
| Price | $380 |
| Order / More Info | canine Factor VIII, Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Lollar P, Fay PJ, Fass DN; Factor VIII and Factor VIIIa. Methods in Enzymology, 222, pg 122, 1993. 2. Hoyer, LW, Wyshock EG, Colman RW, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 109-133, J.B. Lippincott Co., Philadelphia, 1994. 3. Lozier JN, Dutra A. et al: The Chapel Hill hemophilia dog colony exhibits a factor VIII gene inversion. PNAS. 99, pg 12991-96, 2002. 4. Gallo-Penn AM, Shirley PS. et al: Systemic delivery of an adeno-viral viral vector encoding canine factor VIII results in short term phenotypic correction, inhibitor development and liver toxicity in hemophilic dogs. Blood. 97, pg 107-113, 2001. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies