COP1 (N-term), 37-65 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | COP1 (N-term), 37-65 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.35 |
| Applications | Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This COP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COP1. Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing |
| Immunogen | n/a |
| Other Names | [Caspase recruitment domain-containing protein 16; Caspase recruitment domain-only protein 1; CARD-only protein 1; Caspase-1 inhibitor COP; Pseudo interleukin-1 beta converting enzyme; Pseudo-ICE; Pseudo-IL1B-converting enzyme; CARD16; COP; COP1] |
| Gene, Accession # | [CARD16], Gene ID: 114769, NCBI: NP_001017534.1, UniProt: Q5EG05 |
| Catalog # | MBS9211897 |
| Price | $165, $370 |
| Order / More Info | COP1 (N-term), 37-65 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Bailey, S.D., et al. Diabetes Care (2010) In press : Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Wang, X., et al. Biochim. Biophys. Acta 1762(8):742-754(2006) Wang, X., et al. J. Neurosci. 25(50):11645-11654(2005) Lamkanfi, M., et al. J. Biol. Chem. 279(50):51729-51738(2004) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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