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Antigenic Specificity | ILK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Western blot analysis of extracts of various cell lines, using ILK antibody. Integrin-linked kinases (ILKs) couple integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility (1). ILK functions as a scaffold bridging the extracellular matrix (ECM) and growth factor receptors to the actin cytoskeleton through interactions with integrin, PINCH (which links ILK to the RTKs via Nck2), CH-ILKBP and affixin (1). ILK phosphorylates Akt at Ser473, GSK-3 on Ser9, myosin light chain 2 (MLC2) on Ser18/Thr19, as well as affixin (2-5). These phosphorylation events are key regulatory steps in modulating the activities of the targets. ILK activity is stimulated by PI3 |
Immunogen | Immunogen: Recombinant protein of human ILK |
Other Names | [ILK, partial; Integrin-linked protein kinase; integrin-linked protein kinase; integrin linked kinase; 59 kDa serine/threonine-protein kinase; ILK-1; ILK-2; p59ILK], [ILK; ILK; P59; ILK-1; ILK-2; p59ILK; HEL-S-28; ILK1; ILK2] |
Gene, Accession # | [ILK], Gene ID: 3611, NCBI: CAG28601.1 |
Catalog # | MBS419467 |
Price | $385 |
Order / More Info | ILK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |