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Antigenic Specificity | Human Interleukin-1 receptor accessory protein |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Sec |
Immunogen | Immunogen: Recombinant human Interleukin-1 receptor accessory protein protein (21-356aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47056 / sc-47057 / sc-99031 |
Other Names | [IL-1 receptor accessory protein; IL-1RAcP; Interleukin-1 receptor 3; IL-1R-3; IL-1R3; IL1RAP; C3orf13; IL1R3], [IL1RAP; IL1RAP; IL1R3; C3orf13; IL-1RAcP; C3orf13; IL1R3; IL-1 receptor accessory protein; IL-1RAcP; IL-1R-3; IL-1R3] |
Gene, Accession # | [IL1RAP], Gene ID: 3556, NCBI: NP_001161400.1, UniProt: Q9NPH3 |
Catalog # | MBS1495175 |
Price | $120, $160 |
Order / More Info | Human Interleukin-1 receptor accessory protein Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |