Edit |   |
---|---|
Antigenic Specificity | Human Growth factor receptor-bound protein 7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). |
Immunogen | Immunogen: Recombinant human Growth factor receptor-bound protein 7 protein (233-532aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-607 / sc-13954 / sc-606 |
Other Names | [B47; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; GRB7], [GRB7; GRB7] |
Gene, Accession # | [GRB7], Gene ID: 2886, NCBI: NP_001025173.1, UniProt: Q14451 |
Catalog # | MBS1496492 |
Price | $120, $160 |
Order / More Info | Human Growth factor receptor-bound protein 7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |