DOCK8 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DOCK8 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, ratpredicted: porcine, bovine, horse, sheep, rabbit, dog |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: DOCK8 Antibody detects endogenous levels of DOCK8. Description: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing |
| Immunogen | Immunogen: A synthesized peptide derived from human DOCK8. Tissue Specificity: Expressed in peripheral blood mononuclear cells (PBMCs). |
| Other Names | [1200017A24Rik; Dedicator of cytokinesis protein 8; DOCK8; DOCK8_HUMAN; Epididymis luminal protein 205; HEL 205; MRD2; ZIR8] |
| Gene, Accession # | [DOCK8], Gene ID: 81704, NCBI: NP_001180465.1, UniProt: Q8NF50 |
| Catalog # | MBS9611708 |
| Price | $240, $280 |
| Order / More Info | DOCK8 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.