Edit |   |
---|---|
Antigenic Specificity | SMC1 (Phospho-Ser957) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of SMC1 only when phosphorylated at serine 957. Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector bo |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of serine 957 (G-S-S(p)-Q-G) derived from Human SMC1. |
Other Names | [SM1A; SMC1A; SMC1L1; SMC1 alpha protein] |
Gene, Accession # | [SMC1], Gene ID: 8243, NCBI: NP_006297.2, UniProt: Q14683 |
Catalog # | MBS9404807 |
Price | $200, $255 |
Order / More Info | SMC1 (Phospho-Ser957) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |