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Antigenic Specificity | LC3 (APG8) |
Clone | [166AT1234] |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG1kappa |
Format | Protein G purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Monoclonal antibody to detect LC3 in human, mouse and rat samples. Background: Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytopla |
Immunogen | Immunogen: This antibody is generated from mouse immunized with a full length recombinant protein of human LC3 (APG8). Positive Control: WB: Hela cell lysate, IHC: muscle tissue, IF: U251 cells |
Other Names | [MAP1LC3A; Microtubule-associated proteins 1A/1B light chain 3A; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; Microtubule-associated protein 1 light chain 3 alpha], [MAP1LC3A; MAP1LC3A; LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3; MAP1A/MAP1B LC3 A] |
Gene, Accession # | [LC3 (APG8)], Gene ID: 84557, NCBI: NP_115903.1, UniProt: Q9H492 |
Catalog # | MBS840071 |
Price | $335 |
Order / More Info | LC3 (APG8) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |