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Antigenic Specificity | GCK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1.8 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total GCK protein. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infan |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Fusion protein corresponding to a region derived from internal residues of human glucokinase (hexokinase 4) |
Other Names | [GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3] |
Gene, Accession # | [GCK], Gene ID: 2645, NCBI: NP_000153.1, UniProt: P35557 |
Catalog # | MBS9408190 |
Price | $255 |
Order / More Info | GCK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |