Histones Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Histones |
| Clone | [2Q2205] |
| Host Species | Mouse |
| Reactive Species | bovine and hamster. |
| Isotype | IgG2a,k |
| Format | Protein G purified |
| Size | 0.1 mg |
| Concentration | 1 mg/ml |
| Applications | Suitable for use in ELISA (EIA) and Western Blot (WB). Other applications have not been tested. |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes human Histones, H1 and core proteins H2a, H2b, H3, H4. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H1 is located in the nuclear and is necessary for the condensation of nucleosome chains into higher order structures. Histone H1 produces a speckled staining pattern in the nucleus of normal and malignant cells. |
| Immunogen | Immunogen: Histones purified from calf thymus. MW: 15-33kD. |
| Other Names | n/a |
| Gene, Accession # | NCBI: NM_005321.2 |
| Catalog # | MBS602894 |
| Price | $750 |
| Order / More Info | Histones Antibody from MYBIOSOURCE INC. |
| Product Specific References | • 1. Federation Proceedings (1984). 43:2063.• 2. Mizoguchi, E., et al., Antineutrophil Cytoplamic Antibodies in T-Cell Receptor •-Deficient Mice with Chronic Colitis. Gastroenterology (1997) 113:1828-1835.• 3. Feng, H., et al., CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nature Cell Biology (1999) 1:486- 492.• 4. Brimmell, M., et al., High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers. British Journal of Cancer (1999) 81:1042-1051. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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