Phospho-IRAK-4 (pThr345) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-IRAK-4 (pThr345) |
| Clone | [A8A8] |
| Host Species | Mouse |
| Reactive Species | human, mouse, bovine, dog |
| Isotype | IgG1, kappa |
| Format | purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | ELISA, Western Blot, Immunohistochemistry. Optimal dilutions should be determined by researchers for the specific applications. |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody recognizes IRAK-4 (pT345) with a phosphorylated site at Threonine 345. It does not crossreact with non-phosphospecific peptide. IRAK (IL-1 associated serine/threonine kinase) is a critical regulator of Interleukin-1 (IL-1) induced activation of the NFkappaB pathway. IL-1 stimulation leads to the recruitment of interleukin-1 receptor-associated kinase (IRAK) to the IL-1 receptor, where IRAK is phosphorylated, ubiquitinated, and eventually degraded. There are four members (IRAK1, IRAK2, IRAK3/IRAK-M and IRAK4). IRAK-4, recently found another IRAK family member necessary for the IL-1 pathway, is able to phosphorylate IRAK in vitro suggests that IRAK-4 might be the IRAK kinase. IRAK4 is required for the efficient recruitment of IR |
| Immunogen | Antigen Preparation: A synthetic peptide surrounding to the epitope -VMTSR- with a phosphorylation site at Thr345 of human IRAK-4 protein. This sequence is identical among human, mouse, bovine and dog. |
| Other Names | [Ms Phospho-IRAK4 (pT345); Interleukin-1 receptor-associated kinase 4; IRAK-4; IPD1; REN64; NY-REN-64], [IRAK4; IRAK4; IPD1; REN64; NY-REN-64] |
| Gene, Accession # | [IRAK4 (pT345)], Gene ID: 51135, NCBI: NP_001107654.1, UniProt: Q69FE3 |
| Catalog # | MBS462225 |
| Price | $275 |
| Order / More Info | Phospho-IRAK-4 (pThr345) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Li S et al (2002) IRAK-4, A novel member of the IRAK family with the properties of an IRAK-kinase. PNAS 99 (8): 5567-5572. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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