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Antigenic Specificity | CD8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD8 (cluster of differentiation 8, also known as T-cell antigen T8/LEU2) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein.1 The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides, but is frequently lost in other T-cell neoplasms. |
Immunogen | Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the N-terminal of mouse CD8. |
Other Names | [CD8], [CD8A; CD8] |
Gene, Accession # | [CD8], Gene ID: 403158, NCBI: NP_990566.1 |
Catalog # | MBS355076 |
Price | $275 |
Order / More Info | CD8 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Gao G, Jakobsen B (2000). Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol Today 21 (12): 630-6. 2. Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 73. |