DIRAS3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DIRAS3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: DIRAS3 antibody is human specific. DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paternal allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRA |
| Immunogen | Immunogen: DIRAS3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DIRAS3. Buffer: DIRAS3 antibody is supplied in PBS containing 0.02% sodium azide. |
| Other Names | [DIRAS family GTP-binding RAS-like 3; ARHI; NOEY2; DIRAS family, GTP-binding RAS-like 3], [DIRAS3; DIRAS3; ARHI; NOEY2; ARHI; NOEY2; RHOI] |
| Gene, Accession # | [DIRAS3], Gene ID: 9077, NCBI: NP_004666, UniProt: O95661 |
| Catalog # | MBS153530 |
| Price | $375 |
| Order / More Info | DIRAS3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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