Edit |   |
Antigenic Specificity | NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) |
Clone | [SPM564] |
Host Species | Mouse |
Reactive Species | human, mouse, rat, chicken |
Isotype | IgG2b, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing'sarcoma, and was shown to be differentially upregulated in Ewing'sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing'sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors. |
Immunogen | Immunogen: Human NKX2.2 recombinant protein |
Other Names | [Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman], [NKX2-2; NKX2-2; NKX2B; NKX2.2; NKX2.2; NKX2B] |
Gene, Accession # | [NKX2-2], Gene ID: 4821, NCBI: NP_002500.1, UniProt: O95096 |
Catalog # | MBS438359 |
Price | $190, $340, $340 |
Order / More Info | NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Wang, Y.C. et al. (2009) Endocr Relat Cancer 16, 267-79. Yoshida A et. al. Am J Surg Pathol. 2012;36(7):993-9 |