BRSK1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | BRSK1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: BRSK1 antibody detects endogenous levels of total BRSK1. Function: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter rele |
| Immunogen | Immunogen: A synthesized peptide Subcellular Location: Cytoplasm. Nucleus. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV-or MMS-induced DNA damage. Tissue Specificity: Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Dog Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Dog (100%) |
| Other Names | [BR serine/threonine kinase 1; BR serine/threonine protein kinase 1; BR serine/threonine-protein kinase 1; Brain selective kinase 1; Brain-specific serine/threonine-protein kinase 1; BRSK 1; Brsk1; BRSK1_HUMAN; FLJ43009; hSAD1; KIAA1811; Protein kinase SAD1A; SAD 1; SAD1; SAD1 homolog; SAD1 kinase; SAD1A; SADB; SadB kinase short isoform; Serine/threonine kinase SAD B; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog] |
| Gene, Accession # | [BRSK1], Gene ID: 84446, NCBI: NP_115806.1, UniProt: Q8TDC3 |
| Catalog # | MBS9604827 |
| Price | $240, $280 |
| Order / More Info | BRSK1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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