CHEK2 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | CHEK2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | n/a |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, CHEK2 is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. |
| Immunogen | Immunogen: CHEK2 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human CHEK2, identical to the related rat and Rabbit sequences, as the immunogen |
| Other Names | [Affinity Purified Rabbit CHEK2; CHEK2; CHEK2; CHK2 checkpoint homolog; S. pombe; CHK2; CDS1; CHEK2; CHEK-2; CHEK 2; LFS2; PP1425; RP11-436C9.1; HuCds1; CHEK-2; RAD53; CHEK 2] |
| Gene, Accession # | [CHEK2], Gene ID: 11200 |
| Catalog # | MBS5312951 |
| Price | $345 |
| Order / More Info | CHEK2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
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