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Antigenic Specificity | Nlrp3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | fluorescein (FITC) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 a |
Immunogen | Immunogen: Recombinant mouse NACHT, LRR and PYD domains-containing protein 3 protein (1-153AA) |
Other Names | [NACHT; LRR and PYD domains-containing protein 3; Cold autoinflammatory syndrome 1 protein homolog; Cryopyrin; Mast cell maturation-associated-inducible protein 1; PYRI; Nlrp3; Cias1; Mmig1; Nalp3; Pypaf1] |
Gene, Accession # | [Nlrp3], Gene ID: 216799, NCBI: NP_665826.1, UniProt: Q8R4B8 |
Catalog # | MBS7043987 |
Price | $160, $235 |
Order / More Info | Nlrp3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |