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Antigenic Specificity | NRAS (N-term), 72-101 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: chicken, mouse, porcine, rat) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This NRAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the N-terminal region of human NRAS. NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML). |
Immunogen | n/a |
Other Names | [GTPase NRas; Transforming protein N-Ras; NRAS; HRAS1] |
Gene, Accession # | [NRAS], Gene ID: 4893, NCBI: NP_002515.1, UniProt: P01111 |
Catalog # | MBS9213508 |
Price | $165, $370 |
Order / More Info | NRAS (N-term), 72-101 Antibody from MYBIOSOURCE INC. |
Product Specific References | Smalley,K.S., Cancer Res. 68 (14), 5743-5752 (2008) Banerji,U., Mol. Cancer Ther. 7 (4), 737-739 (2008) |