Phospho-ERBB2 (Y1127) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-ERBB2 (Y1127) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA), Immunofluorescence (IF), Dot Blot (DB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1127 of human ERBB2. This gene encodes a member of the epidermal growth factor(EGF) receptor family of receptor tyrosine kinases. This proteinhas no ligand binding domain of its own and therefore cannot bindgrowth factors. However, it does bind tightly to other ligand-boundEGF receptor family members to form a heterodimer, stabilizingligand binding and enhancing kinase-mediated activation ofdownstream signalling pathways, such as those involvingmitogen-activated protein kinase and phosphatidylinositol-3 kinase.Allelic variations at amino acid positions 654 an |
| Immunogen | n/a |
| Other Names | [Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD340; ERBB2; HER2; MLN19; NEU; NGL] |
| Gene, Accession # | [ERBB2], Gene ID: 2064, NCBI: NP_001005862.1, UniProt: P04626 |
| Catalog # | MBS9214834 |
| Price | $165, $370 |
| Order / More Info | Phospho-ERBB2 (Y1127) Antibody from MYBIOSOURCE INC. |
| Product Specific References | References for protein: 1.Geradts, J., et al. Cancer Invest. 28(9):969-977(2010) 2.Zaoui, K., et al. Proc. Natl. Acad. Sci. U.S.A. 107(43):18517-18522(2010) 3.Oliveras, G., et al. Ann. N. Y. Acad. Sci. 1210, 86-92 (2010) 4.Han, J.S., et al. Anticancer Res. 30(9):3407-3412(2010) 5.Stackievicz, R., et al. Isr. Med. Assoc. J. 12(5):290-295(2010) References for MCF7 cell line: 1.Soule, HD; Vazquez J; Long A; Albert S; Brennan M. (1973). A human cell line from a pleural effusion derived from a breast carcinoma. Journal of the National Cancer Institute 51 (5): 1409-1416. [PMID 4357757]. 2.Levenson, AS; Jordan VC. (1997). MCF-7: the first hormone-responsive breast cancer cell line. Cancer Research 57 (15): 3071-3078. [PMID 9242427]. 3.Lacroix, M; Leclercq G. (2004). Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Research and Treatment 83 (3): 249-289.[PMID 14758095]. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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