FHIT (N-Term) Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | FHIT (N-Term) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.05 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This FHIT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between19-54 amino acids from human FHIT. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of |
| Immunogen | n/a |
| Other Names | [Purified Rabbit (Pab); Bis(5'-adenosyl)-triphosphatase; AP3A hydrolase; AP3Aase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein; FHIT] |
| Gene, Accession # | [FHIT], Gene ID: 2272, NCBI: NP_001159715.1, UniProt: P49789 |
| Catalog # | MBS9216060 |
| Price | $165, $370 |
| Order / More Info | FHIT (N-Term) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Ohta M.,et al.Cell 84:587-597(1996).Druck T.,et al.Cancer Res. 57:504-512(1997).Corominas R.,et al.Nat. Commun. 5:3650-3650(2014).Naqvi S.R.A.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.Ota T.,et al.Nat. Genet. 36:40-45(2004). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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