Siglec-H, Mouse Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Siglec-H, Mouse |
| Clone | 440c |
| Host Species | Rat |
| Reactive Species | n/a |
| Isotype | IgG2b |
| Format | biotin conjugate |
| Size | 0.05 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody 440c reacts with Siglec-H, a cell-surface receptor molecule selectively expressed on murine natural interferon producing cells (IPC), also called mouse plasmacytoid dendritic cells (pDC). Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and |
| Immunogen | n/a |
| Other Names | [sialic acid binding Ig-like lectin H; sialic acid binding Ig-like lectin H; SIGLEC-like protein; sialic acid binding Ig-like lectin H], [Siglech; Siglec-H; 6430529G09Rik] |
| Gene, Accession # | [Siglec-H], Gene ID: 233274, NCBI: NP_848821.2 |
| Catalog # | MBS584271 |
| Price | $425 |
| Order / More Info | Siglec-H, Mouse Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Blasius, A et al; Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12. Blood 2006, 107: 2474 2. Blasius, A et al; A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha. Blood 2004, 103: 4201 3. Colonna, M et al; Plasmacytoid dendritic cells in immunity. Nat Immunol 2004, 5: 1219 4. Seth, S et al; CCR7 Essentially Contributes to the Homing of Plasmacytoid Dendritic Cells to Lymph Nodes under Steady-State As Well As Inflammatory Conditions. J Immunol 2011, 186: 3364 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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