MBNL1 (C-term), 255-284 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | MBNL1 (C-term), 255-284 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This MBNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-284 amino acids from the C-terminal region of human MBNL1. Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosom |
| Immunogen | n/a |
| Other Names | [Muscleblind-like protein 1; Triplet-expansion RNA-binding protein; MBNL1; EXP; KIAA0428; MBNL] |
| Gene, Accession # | [MBNL1], Gene ID: 4154, NCBI: NP_066368.2, UniProt: Q9NR56 |
| Catalog # | MBS9201830 |
| Price | $165, $370 |
| Order / More Info | MBNL1 (C-term), 255-284 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Sen, S., et al. J. Biol. Chem. 285(33):25426-25437(2010) Arambula, J.F., et al. Proc. Natl. Acad. Sci. U.S.A. 106(38):16068-16073(2009) Cardani, R., et al. Neuromuscul. Disord. 19(5):335-343(2009) Holt, I., et al. Am. J. Pathol. 174(1):216-227(2009) Teplova, M., et al. Nat. Struct. Mol. Biol. 15(12):1343-1351(2008) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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