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Antigenic Specificity | H3F3B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of hi |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human H3F3B (NP 002098.1). |
Other Names | [H3.3B] |
Gene, Accession # | [H3F3B], NCBI: NP_002098.1, UniProt: P84243 |
Catalog # | MBS8547802 |
Price | $280 |
Order / More Info | H3F3B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |