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Antigenic Specificity | ICT1 |
Clone | [AT1E9] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1,k |
Format | Protein A purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1mg/ml |
Applications | ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Peptidyl-tRNA hydrolase ICT1 acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. This neoplastic-induced deviation is marked by a change in expression of several mRNAs. ICT1 is a member of the prokaryotic/mitochondrial release factor family whose expression is downregulated over 4 fold upon colon stem cell differentiation. This downregulation of ICT1 could l |
Immunogen | Immunogen: Recombinant human ICT1 (30-206aa) purified from E. coli |
Other Names | [Peptidyl-tRNA hydrolase ICT1 mitochondrial; Peptidyl-tRNA hydrolase ICT1; mitochondrial; DS-1; DS1], [MRPL58; MRPL58; DS1; DS-1; ICT1; MRP-L58; MRP-L58; DS-1] |
Gene, Accession # | [ICT1], Gene ID: 3396, NCBI: NP_001536, UniProt: Q14197 |
Catalog # | MBS200279 |
Price | $240, $315 |
Order / More Info | ICT1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Richer, R, et al. (2010) EMBO J 17;29 (6): 1116-25; van Belzen, N., et al. (1995) Eur J Biochem 15;234 (3):843-8. |