ICT1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityICT1
Clone[AT1E9]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1,k
FormatProtein A purified
Size0.05 mL, 0.1 mL
Concentration1mg/ml
ApplicationsELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
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DescriptionPeptidyl-tRNA hydrolase ICT1 acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. This neoplastic-induced deviation is marked by a change in expression of several mRNAs. ICT1 is a member of the prokaryotic/mitochondrial release factor family whose expression is downregulated over 4 fold upon colon stem cell differentiation. This downregulation of ICT1 could l
ImmunogenImmunogen: Recombinant human ICT1 (30-206aa) purified from E. coli
Other Names[Peptidyl-tRNA hydrolase ICT1 mitochondrial; Peptidyl-tRNA hydrolase ICT1; mitochondrial; DS-1; DS1], [MRPL58; MRPL58; DS1; DS-1; ICT1; MRP-L58; MRP-L58; DS-1]
Gene, Accession #[ICT1], Gene ID: 3396, NCBI: NP_001536, UniProt: Q14197
Catalog #MBS200279
Price$240, $315
Order / More InfoICT1 Antibody from MYBIOSOURCE INC.
Product Specific ReferencesRicher, R, et al. (2010) EMBO J 17;29 (6): 1116-25; van Belzen, N., et al. (1995) Eur J Biochem 15;234 (3):843-8.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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