Edit |   |
---|---|
Antigenic Specificity | CCP110 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.6mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total CCP110 protein. Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545?PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). |
Immunogen | Immunogen: Synthetic peptide of human CCP110 Immunogen Type: Peptide |
Other Names | [CP110; Cep110] |
Gene, Accession # | [CCP110], Gene ID: 9738, NCBI: NP_055526, UniProt: O43303 |
Catalog # | MBS9429896 |
Price | $255 |
Order / More Info | CCP110 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |