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Antigenic Specificity | HLA-DMB |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes th |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthetic peptide contain a sequence corresponding to a region within amino acids 199 and 263 of Human HLA-DMB |
Other Names | [RING7; D6S221E] |
Gene, Accession # | [HLA-DMB], Gene ID: 3109, NCBI: NP_002109 |
Catalog # | MBS9410014 |
Price | $320 |
Order / More Info | HLA-DMB Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |