Beclin1 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Beclin1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | n/a |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | 1mg/ml |
| Applications | Immunoblotting (IB), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody recognizes human and rat Beclin 1. Autophagy is a catabolic process that results in the degradation of bulk cytoplasmic contents within autophagosomes and lysosomes. Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy. It interacts with several cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP3R, PINK and survivin) to regulate the lipid kinase Vps-34 protein and promote formation of Beclin 1-Vps34-Vps15 core complexes, thereby inducing autophagy. In contrast, the BH3 domain of Beclin 1 is bound to, and inhibited by Bcl-2 or Bcl-XL. This interaction can be disrupted by phosphorylation of Bcl-2 and Beclin 1, or ubiquitination of Beclin 1. Beclin 1 dysfunction has been im |
| Immunogen | Antigen: Synthetic peptide corresponding to mid-protein amino acids of human Beclin 1. |
| Other Names | [beclin-1 isoform a; Beclin-1; beclin-1; beclin 1; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197], [BECN1; BECN1; ATG6; VPS30; beclin1; GT197] |
| Gene, Accession # | Gene ID: 8678, NCBI: NP_001300927.1, UniProt: Q14457 |
| Catalog # | MBS191009 |
| Price | $410 |
| Order / More Info | Beclin1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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