Mst1/2 (Phospho-Thr183) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Mst1/2 (Phospho-Thr183) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Mst1/2 (Phospho-Thr183) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous levels of Mst1/2 only when phosphorylated at threonine 183. Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of |
| Immunogen | Immunogen Type: peptide Immunogen Description: Peptide sequence around phosphorylation site of threonine 183 (R-N-T(p)-V-I) derived from Human Mst1/2. |
| Other Names | [EC 2.7.11.1; MST-1; Mammalian STE20-like protein kinase 1; STE20-like kinase MST1; STK4; Serine/threonine protein kinase 4; Serine/threonine protein kinase Krs-2; kinase MST1; serine/threonine kinase 4; STE20-like kinase MST1; Yeast Sps1/Ste20-related kin] |
| Gene, Accession # | [Mst1/2], Gene ID: 6789, NCBI: NP_006273.1, UniProt: Q13043 |
| Catalog # | MBS9403915 |
| Price | $200, $255 |
| Order / More Info | Mst1/2 (Phospho-Thr183) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies