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Antigenic Specificity | PIP2 |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG2b |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Species independent. Metabolism of inositol phospholipids by intracellular signaling mediators is fundamental to signal transduction in eukaryotic cells. PI-4,5-P2 (Phosphatidylinositol 4,5-bisphosphate; PIP2) can be synthesized by phosphorylation of PI-4-P by type I phosphatidylinositol phosphate kinase (PIP5K I), or phosphorylation of PI-5-P by type II PIPK (PIP4K II). PI-4,5-P2 regulation of cellular calcium levels involves its hydrolysis by Phospholipase C (PLC) to produce inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), which serve as second messengers in the import of calcium via IP3-sensitive ion channels and in the activation of PKC, respectively. |
Immunogen | Immunogen: Native PIP2 from bovine spinal cord. |
Other Names | [Phosphatidylinositol 4,5-bisphosphate; PtdIns(4,5)P2], [PIP2] |
Gene, Accession # | [PIP2], NCBI: AFC90119.1 |
Catalog # | MBS565167 |
Price | $435 |
Order / More Info | PIP2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |