Cyclin D1 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Cyclin D1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Activity of the cyclindependent kinases CDK4 and CDK6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with CDK inhibitors of the Cip/Kip or INK family of proteins (1). The inactive ternary complex of cyclin D/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to effect progression through the restriction point and pRbdependent entry into Sphase (2). The active complex of cyclin D/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/Sphase gene expression (3). Levels of cyclin D protein drop upon withdrawa |
| Immunogen | Immunogen: A synthetic -peptide of Human Cyclin D1 |
| Other Names | [CCND1; Cyclin D1; Cyclin D1; CCND1; BCL1; D11S287E; PRAD1; U21B31; G1/Sspecific cyclin-D1; BCL-1 oncogene; PRAD1 oncogene;], [CCND1; CCND1; BCL1; PRAD1; U21B31; D11S287E; BCL1; PRAD1; BCL-1] |
| Gene, Accession # | Gene ID: 595, NCBI: NP_444284.1, UniProt: P24385 |
| Catalog # | MBS125892 |
| Price | $200, $275, $430 |
| Order / More Info | Cyclin D1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Hirai, H. et al. (1995) Mol. Cell. Biol. 15, 2672-2681. 2. Sherr, C.J. (1996) Science 274, 1672-1677. 3. Lukas, J. et al. (1996) Mol. Cell. Biol. 16, 6917-6925. 4. Diehl, J.A. et al. (1997) Genes Dev. 11, 957-972. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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