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Antigenic Specificity | LCN2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total LCN2 antibody. Lipocalin-2, a member of the lipocalin family of proteins, was originally identified as a gelatinase-associated component of neutrophil secretory granules (1). Lipocalin-2 is involved in innate immunity, iron homeostasis, and apoptosis. Lipocalin-2 limits bacterial growth by binding to bacterial siderophores and sequestering iron (2-4). In mammalian cells, iron-loaded lipocalin-2 binds to its receptor, 24p3R, and is internalized, thereby releasing iron and increasing the intracellular iron concentration (5). Conversely, iron-free lipocalin-2 promotes apoptosis (5). Lipocalin-2 is also expressed in adipose tissue and promotes insulin resistance in cultured mouse adipocytes (6). |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human LCN2. |
Other Names | [LCN2; 24p3; MSFI; NGAL; Lipocalin-2] |
Gene, Accession # | [LCN2], Gene ID: 3934, NCBI: NP_005555.2, UniProt: P80188 |
Catalog # | MBS9404930 |
Price | $255 |
Order / More Info | LCN2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |