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Antigenic Specificity | TOLLIP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human TOLLIP (NP 061882.2). |
Other Names | [IL-1RAcPIP] |
Gene, Accession # | [TOLLIP], Gene ID: 54472, NCBI: NP_061882.2, UniProt: Q9H0E2 |
Catalog # | MBS8544876 |
Price | $280 |
Order / More Info | TOLLIP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |