cyclin A (E67.1) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | cyclin A (E67.1) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | cow, hamster, mink, mouse, human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | 0.100 mg/ml |
| Applications | Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Reacts with cyclin A of cow, hamster, mink, mouse, and human origin. During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by activating Cdks (1,2). Cyclin A regulates at least two cdks, Cdc2 p34 and Cdk2, and is believed to be necessary for progression through S phase and is active during the G2-M transition (1&3,4). Cyclin B1 also associates with Cdc2 p34 and this complex is requisite for the G2-M progression. The Cyclin B1/Cdc2 p34 complex is known as MPF, M-phase kinase, maturation-promoting factor, or M-phase specific histone kinase, is widely accepted as the trigger of mitosis in all organisms (5-9). |
| Immunogen | Origin: Cyclin A (E67.1) is provided as mouse monoclonal IgG2a derived from a mouse immunized with bovine cyclin A. The epitope for this antibody has been mapped to a region containing the sequence LDYP. This epitope maps within amino acids 144-148 of human cyclin A2. |
| Other Names | [cyclin-A2; Cyclin-A2; cyclin-A2; cyclin A2], [CCNA2; CCNA2; CCN1; CCNA; CCN1; CCNA; Cyclin-A] |
| Gene, Accession # | Gene ID: 890, NCBI: NP_001228.1, UniProt: P20248 |
| Catalog # | MBS440094 |
| Price | $340 |
| Order / More Info | cyclin A (E67.1) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Bandara LR, Adamczewski JP, Zamanian M, Poon RY, Hunt T, Thangue NB. 1992. Cyclin A recruits p33cdk2 to the cellular transcription factor DRTF1. J Cell Sci Suppl 16: 77-85.2. Desdouets C, Sobczak-Thepot J, Murphy M, Brechot C. 1995. Cyclin A: Function and expression during cell proliferation. Prog Cell Cycle Res 1:115-123.3. Brechot C. 1993. Oncogenic activation of cyclin A. Curr Opin Genet Dev 3(1): 11-18.4. Goldstone S, Pavey S, Forrest A, Sinnamon J, Gabrielli B. 2001. Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR. Oncogene 20(8): 921-932.5. Liu D, Liao C, Wolgemuth DJ. 2000. A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice. Dev Biol 224(2): 338-400.6. Hoffman I, Clarke PR, Marcotte MJ, Karsenti E, Draetta G. 1993. Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J 12(1): 53-63. 7. Kishimoto T, Okumura E. 1997. In vivo regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2. Prog Cell Cycle Res 3:241-249.8. Baratte B, Meijer L, Galaktionov K, Beach D. 1992. Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase. Anticancer Res 12(3): 873-880.9. Thron CD. 1994. Theoretical dynamics of the cyclin B-MPF system: a possible role for p13suc1. Biosystems 32(2):97-109. |
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MYBIOSOURCE INC.
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