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Antigenic Specificity | Centaurin-beta1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Centaurin-beta-1 antibody detects endogenous levels of Centaurin-beta-1. Function: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.Subunit Structure: Banana-shaped homodimer laterally assembling into tetramers, the tetramers further pack helically onto the membrane. Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1. Interacts with ITGB1; required fo |
Immunogen | Immunogen: A synthesized peptide derived from human Centaurin-beta-1 Subcellular Location: Endosome Tissue Specificity: Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. |
Other Names | [ACAP 1; ACAP1; ACAP1_HUMAN; Arf GAP with coiled coil ANK repeat and PH domains 1; Arf GAP with coiled coil, ankyrin repeat, and pleckstrin homology domains 1; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; CENT B1; Centaurin beta 1; Centaurin-beta-1; CENTB 1; Cnt b1; Cnt-b1; Cntb1; KIAA0050] |
Gene, Accession # | [ACAP1], Gene ID: 9744, NCBI: NP_055531.1, UniProt: Q15027 |
Catalog # | MBS9603171 |
Price | $240, $280 |
Order / More Info | Centaurin-beta1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |