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Antigenic Specificity | Mouse Fgfr4 (Center) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | purified |
Size | 0.08 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This Mouse Fgfr4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 448-482 amino acids from the Central region of Mouse Fgfr4. Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the prod |
Immunogen | n/a |
Other Names | [Fibroblast growth factor receptor 4; FGFR-4; Protein-tyrosine kinase receptor MPK-11; CD334; Fgfr4; Fgfr-4; Mpk-11] |
Gene, Accession # | [Fgfr4], Gene ID: 14186, NCBI: NP_032037.2, UniProt: Q03142 |
Catalog # | MBS9205497 |
Price | $150 |
Order / More Info | Mouse Fgfr4 (Center) Antibody from MYBIOSOURCE INC. |
Product Specific References | Stark K.L.,et al.Development 113:641-651(1991). Kwiatkowski B.A.,et al.J. Cell. Physiol. 215:803-817(2008). Carninci P.,et al.Science 309:1559-1563(2005). Gilardi-Hebenstreit P.,et al.Oncogene 7:2499-2506(1992). Weinstein M.,et al.Development 125:3615-3623(1998). |