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Antigenic Specificity | IL10 (Center), 27-53 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: EBV, monkey) |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This IL10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-53 amino acids from the Central region of human IL10. The protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal t |
Immunogen | n/a |
Other Names | [Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10] |
Gene, Accession # | [IL10], Gene ID: 3586, NCBI: NP_000563.1, UniProt: P22301 |
Catalog # | MBS9207395 |
Price | $165, $370 |
Order / More Info | IL10 (Center), 27-53 Antibody from MYBIOSOURCE INC. |
Product Specific References | Trajkov,D., et.al., Indian J Tuberc 56 (3), 117-131 (2009) Kim,J.M., et.al., J. Immunol. 148 (11), 3618-3623 (1992) |