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Antigenic Specificity | RPTOR |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA tran |
Immunogen | Immunogen: Recombinant human Regulatory-associated protein of mTOR protein (13-128AA) |
Other Names | [Regulatory-associated protein of mTORRaptor; p150 target of rapamycin (TOR)-scaffold protein; RPTOR; KIAA1303; RAPTOR] |
Gene, Accession # | [RPTOR], Gene ID: 57521, NCBI: NP_001156506.1, UniProt: Q8N122 |
Catalog # | MBS7050835 |
Price | $160, $235 |
Order / More Info | RPTOR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |