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Antigenic Specificity | AKT1S1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTO |
Immunogen | Immunogen: Recombinant human Proline-rich AKT1 substrate 1 protein (C-125AA) |
Other Names | [Proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate; AKT1S1] |
Gene, Accession # | [AKT1S1], Gene ID: 84335, NCBI: NP_001092102.1, UniProt: Q96B36 |
Catalog # | MBS7045763 |
Price | $120, $160 |
Order / More Info | AKT1S1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |