GCLM Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityGCLM
Clone[AT2D12]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1,k
FormatProtein G purified
Size0.05 mL, 0.1 mL
Concentration1mg/ml
ApplicationsELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
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DescriptionGCLM (Glutamate-cysteine ligase, modifier subunit), also known as gamma-glutamylcysteine synthetase, is first rate limiting enzyme of glutathione synthesis. GCLM is heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. GCLM deficiency has been implicated in some forms of hemolytic anemia. Also, GCLM is a molecular target for amelioration of cisplatin restance in lung cancer.
ImmunogenImmunogen: Recombinant human GCLM (1-274aa) purified from E. coli
Other Names[Glutamate-cysteine ligase modifier subunit; Glutamate-cysteine ligase; modifier subunit; GLCLR], [GCLM; GCLM; GLCLR; GLCLR]
Gene, Accession #[GCLM], Gene ID: 2730, NCBI: NP_002052, UniProt: P48507
Catalog #MBS200243
Price$240, $315
Order / More InfoGCLM Antibody from MYBIOSOURCE INC.
Product Specific ReferencesDickinson D.A., et al. (2005) Free Radic Biol Med 37 (8): 1152-1159; Inoue Y., et al. (2003) Int J Oncol 23 (5): 1333-1339; Robertson N.G., et al. (1995) Genomics 23 (1): 42-50
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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