MCPl Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | MCPl |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 0.1 mg, 0.2 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MCP-1 belongs to the family of chemotactic cytokines.MCP-1 is expressed by monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cell, osteoblastic cells. MCP-1 has been shown to exhibit biological activities other than Chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK. Elevated levels of MCP-1 are observed in atherosclerotic plaques that are rich in macrophages. The factor activates the tumoricidal activity of monocytes and macrophages in vivo. It regulates the expression of cell surface antigens (CD11c, CD11b) and the expression of cytokines (IL1, IL6). MCP-1 is a potent activator of human basophils, inducing degranulation and the release of histamines. In basophils activat |
| Immunogen | Source Note: Polyclonal MCP-1 (CCL2) antibody was produced from sera of rabbits immunized with synthetic protein containing MCP-1 antigenic determinants. |
| Other Names | [Rabbit MCP-1 purified; mcp-1; mcp1; ccl2; ccl-2; pab;], [CCL2; MCP1; SCYA2; MCAF; MCP-1] |
| Gene, Accession # | [MCP-1], Gene ID: 6347, NCBI: NP_002973.1, UniProt: P13500 |
| Catalog # | MBS551047 |
| Price | $280, $385 |
| Order / More Info | MCPl Antibody from MYBIOSOURCE INC. |
| Product Specific References | • rationally evolving mcp-1/ccl2 into a decoy protein with potent anti-inflammatory activity in vivo.J. Biol. Chem., Mar 2010; 285: 8782 - 8792. • association of the mcp-1 -2518 a/g polymorphism and no association of its receptor ccr2 -64 v/i polymorphism with lupus nephritis.J Rheumatol, Mar 2010; 10.3899/jrheum.090681. • mcp-1/ccl2 modifies axon properties in a pmp22-overexpressing mouse model for charcot-marie-tooth 1a neuropathy.Am. J. Pathol., Mar 2010; 176: 1390 - 1399. • critical protective role for mcp-1 in pneumonic burkholderia mallei infection.J. Immunol., Feb 2010; 184: 1445 - 1454. • thioredoxin 1 downregulates mcp-1 secretion in human endothelial cells by suppressing nuclear translocation of activator protein 1 and redox factor-1.Am J Physiol Cell Physiol, Dec 2009; 10.1152/ajpcell.00223.2009. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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