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Antigenic Specificity | Arkadia |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein. The protein encoded by RNF111 (ring finger protein 111) is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF)-beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of RNF111 results in multiple transcript variants encoding distinct isoforms. |
Immunogen | Immunogen: Synthesized peptide derived from the C-terminal region of human Arkadia at AA range: 870-950 |
Other Names | [Rabbit Arkadia; RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111] |
Gene, Accession # | Gene ID: 54778, NCBI: NP_001257457.1, UniProt: Q6ZNA4 |
Catalog # | MBS9706306 |
Price | $130, $220, $325 |
Order / More Info | Arkadia Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |