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Antigenic Specificity | IL-18 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | Protein G purified |
Size | 0.1 mg, 0.2 mg |
Concentration | n/a |
Applications | Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | IL18 is synthesized as a biologically inactive precursor protein that has limited biological activity. The proform of IL18 is processed by one of the caspases, Caspase-1, to generate the 18 kDa bioactive molecule. IL-18 is produced during the acute immune response by macrophages and immature dendritic cells. Interleukin-18 is expressed by a variety of immune and non-immune cells, including monocytes and macrophages. IL18 is one of the pro- inflammatory cytokines. The activities of IL18 appear to be species specific. An important function of IL18 is the regulation of functionally distinct subsets of T-helper cells required for cell mediated immune responses (Nakanishi et al, 2001). IL18 functions as a growth and differentiation factor for Th |
Immunogen | Source Note: Polyclonal Interleukin-18 antibody was produced from sera of rabbits immunized with synthetic protein containing Interleukin-18 N-terminus antigenic determinants. |
Other Names | [Rabbit IL-18 purified; IGIF; IL1F4; IL18; il-18;; pab], [IL18; IGIF; IL1F4; IL-18; IFN-gamma-inducing factor; IL-1 gamma] |
Gene, Accession # | [IL-18], Gene ID: 3606, NCBI: NP_001230140.1, UniProt: Q14116 |
Catalog # | MBS551052 |
Price | $280, $385 |
Order / More Info | IL-18 Antibody from MYBIOSOURCE INC. |
Product Specific References | • IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.PNAS, Sep 2009; 10.1073/pnas.0908924106. • IL-18 and urinary ngal predict dialysis and graft recovery after kidney transplantation.J. Am. Soc. Nephrol., Sep 2009; 10.1681/ASN.2009030264. • a functional polymorphism in IL-18 is associated with severity of bronchial asthma.Am. J. Respir. Crit. Care Med., Sep 2009; 10.1164/rccm.200905-0652 degree C. • il-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection.J. Immunol., Sep 2009; 183: 3324 - 3331. • neutrophil chemokines and their role in IL-18-mediated increase in neutrophil o2- production and intestinal edema following alcohol intoxication and burn injury.Am J Physiol Gastrointest Liver Physiol, Aug 2009; 297: G340 - G347. |